Welcome to the Roe Lab!

Protein backbone editing using acyl chemistry for next-generation therapeutics

Research

The Roe Lab develops protein backbone editing strategies that leverage acyl chemistry to expand the capabilities of next-generation therapeutics. We build simple, site-selective tools compatible with cellular expression and therapeutic discovery workflows.

Our work is inspired by nature’s acyl transfer chemistry and focuses on (1) probing and manipulating acyl chemistry mechanisms to unlock new chemical diversity, (2) programmable protein backbone editing in cells, and (3) applications in therapeutic discovery platforms. We are a chemical biology group working at the intersection of synthetic biology, protein engineering, and biophysics.

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